论文部分内容阅读
目的:探讨舒尔经颗粒联合戊酸雌二醇预防人工流产术后宫腔粘连的临床疗效和安全性。方法:人工流产术患者240例根据入院顺序分为观察组和对照组各120例。对照组患者术后均给予戊酸雌二醇治疗,观察组患者在对照组基础上加用舒尔经颗粒;治疗时间均为3周。观察两组患者治疗后阴道出血时间和出血量,月经复潮等指标及药品不良反应情况;比较两组患者手术前后血清纤连蛋白(FN)、人层黏蛋白(LN)、血管内皮生长因子(VEGF)水平变化;比较两组术后12个月宫腔粘连情况。结果:观察组阴道出血时间、出血量均显著优于对照组(P<0.05),术后月经量正常率高于对照组(P<0.05)。术后2周,观察组患者血清FN、LN、VEGF水平均显著低于对照组(P<0.05);术后12个月,观察组宫腔粘连发生率明显低于对照组(P<0.05)。两组药品不良反应发生率差异无统计学意义(P>0.05)。结论:舒尔经颗粒联合戊酸雌二醇预防人工流产术后宫腔粘连的疗效优于单用戊酸雌二醇。
Objective: To investigate the clinical efficacy and safety of Shure via particle combined with estradiol valerate in prevention of intrauterine adhesions after induced abortion. Methods: 240 cases of induced abortion patients were divided into observation group and control group according to admission order of 120 cases. Patients in the control group were given estradiol valerate after operation. Patients in the observation group were treated with Shureijing granules on the basis of the control group. The treatment time was 3 weeks. The duration of vaginal bleeding, bleeding volume, menstrual cramps and adverse drug reactions were observed after treatment. The changes of serum fibronectin (FN), laminin (LN), vascular endothelial growth factor (VEGF) levels in the two groups were compared. Intrauterine adhesions were compared between the two groups at 12 months after operation. Results: The vaginal bleeding time and bleeding volume in the observation group were significantly better than those in the control group (P <0.05). The postoperative menstrual flow rate was higher than that in the control group (P <0.05). The levels of serum FN, LN and VEGF in the observation group were significantly lower than those in the control group at 2 weeks after operation (P <0.05). At 12 months after operation, the incidence of intrauterine adhesions in the observation group was significantly lower than that of the control group (P <0.05) . There was no significant difference in the incidence of adverse drug reactions between the two groups (P> 0.05). CONCLUSIONS: Shure’s combination of granule and estradiol valerate in preventing intrauterine adhesions after induced abortion is superior to estradiol valerate alone.