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用放射免疫法测定22名(男16,女6)正常人安静卧位时血浆心钠素(ANP)、环磷腺苷(cAMP)、环磷鸟苷(cGMP)在24、8和16时的值,同时测定血清钠(Na)、收缩压(SBP)和心率(HR)值。结果16时值与24时值比较,cAMP(20.1±5.3对14.3±6.9nmol/L,P<0.05),cGMP(6.2±2.4对4.8±1.6nmol/L,P<0.05),ANP(203.4±127.5对64.4±46.0ng/L,P<0.01),Na (14.3±19.3对123,6±26.8nmol/L,P<0.05),SBP(15.7±2.9对14.1±1.9kPa,P<0.05)和HR(80.2±12.4对72.6±10.2次/min,P<0.05)明显升高,而8时与24时比较仅ANP(196.3±140.6ng/L)显著升高(P<0.01),其他各值无明显变化(P>0.05);男女之间各值无差异(P>0.05)。ANP与cAMP、cGMP、Na、SBP和HR无相关(P>0.05)。提示正常人在安静卧位状态下,为维持机体正常代谢,ANP、cAMP、cGMP、Na、SBP和HR呈现的昼夜变化,其值以午夜24时最低,这一变化可能由于伴随心房轻度扩张后,通过神经体液调节从而使上述各值在午夜的分泌抑制出现最低值。
Radioimmunoassay was used to determine the plasma level of ANP, cAMP and cGMP in 22 (male 16, female 6) normal subjects at 24, 8 and 16 The values of serum sodium (Na), systolic blood pressure (SBP) and heart rate (HR) were measured at the same time. Results Compared with the 24th hour, the 16 hour value of cAMP (20.1 ± 5.3 vs 14.3 ± 6.9nmol / L, P <0.05), cGMP (6.2 ± 2.4 vs 4.8 ± 1.6nmol / L, P <0.05), ANP (14.3 ± 19.3 vs 123.6 ± 26.8nmol / L, P <0.05), SBP (15.7 ± 2.9 vs 14.1 ± 1.9kPa, P <0.05) and HR (80.2 ± 12.4 vs 72.6 ± 10.2 times / min, P <0.05), but only ANP (196.3 ± 140.6ng / L) was significantly higher at 8 and 24 hours (P <0.01) No significant change (P> 0.05); There was no significant difference between male and female (P> 0.05). There was no correlation between ANP and cAMP, cGMP, Na, SBP and HR (P> 0.05). It is suggested that the normal circadian changes of ANP, cAMP, cGMP, Na, SBP and HR in the normal state under the condition of resting position are the lowest at 24 o’clock midnight, which may be due to the mild atrial dilatation After that, through neurohumoral regulation so that the above values at the midnight secretion inhibition appears the lowest value.