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目的:研究在腺行膀胱炎(cystitis glandularis,CG)以及膀胱癌(bladder carcinoma,BC)中livin和caspase-9的表达,探讨腺性膀胱炎与膀胱癌可能存在的关系。方法:收集哈尔滨医科大学附属第三医院2014年1月~2014年10月住院患者60例组织石蜡标本,应用SP(streptavidin-perosidase)法检测livin和caspase-9在腺性膀胱炎组织(30例)、膀胱癌组织(30例)和正常组织(30例)中的表达。结果:正常膀胱、CG和BC组织中livin阳性表达率分别为0/30,9/30(30%)和14/30(46.67%),差异有统计学意义(P<0.05);caspase-9在正常膀胱、CG和BC组织中的阳性表达率分别20/30(66.67%),15/30(50%),3/30(10%),差异有统计学意义(P<0.05)。结论:腺性膀胱炎可能是正常膀胱组织向膀胱腺癌发展的一个中间阶段,在CG向BC发展过程中livin和caspase-9的异常表达具有普遍性,临床上应积极治疗并密切随访,并可将livin和caspase-9作为诊断早期膀胱癌的检测指标。
Objective: To investigate the expression of livin and caspase-9 in cystitis glandularis (CG) and bladder carcinoma (BC) and explore the possible relationship between cystitis glandularis and bladder cancer. Methods: Sixty paraffin-embedded specimens from hospitalized patients in the Third Affiliated Hospital of Harbin Medical University from January 2014 to October 2014 were collected for the detection of livin and caspase-9 in glandular cystitis tissues by streptavidin-perosidase (SP ), Bladder cancer (30 cases) and normal tissue (30 cases). Results: The positive rates of livin expression in normal bladder, CG and BC tissues were 0/30, 9/30 (30%) and 14/30 (46.67%), respectively, with statistical significance (P <0.05) The positive expression rates in normal bladder, CG and BC tissues were 20/30 (66.67%), 15/30 (50%) and 3/30 (10%), respectively. The difference was statistically significant (P <0.05). Conclusions: Glandular cystitis may be an intermediate stage in the development of normal bladder tissue to the cystadenocarcinoma. Abnormal expression of livin and caspase-9 in the process of CG to BC development is universal, and should be actively treated and closely followed up clinically. Livin and caspase-9 can be used as a diagnostic indicator of early stage bladder cancer.