Objective To discuss the surgical procedures and its advantages and disadvantages.MethodsThe unilateral trans septal endonasal approach was employed. Zero degree neuroendoscope was used for nasal mucosal dissection and exploration of anterior wall of sphenoid sinus. The sphenoidotomy was done with the anatomic landmark of inferior margin of middle turbinate and ostia. After the identification of internal carotid artery and optic nerve, the pituitary fossa was opened. Then cut the dura, the margin between adenoma and normal tissue was very clear under endoscope, tumor can be removed safely. There were two patients with suprasellar extension, 30-degree endoscope was used and excellent visualization and tumor removal were obtained. ResultsNo severe complication occurred.ConclusionEndoscopic assisted transsphenoidal pituitary surgery is practical because the operation is done under excellent illumination and visualization.