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目的探讨食管鳞状细胞癌(ESCC)的细胞分化程度、浸润深度(T分期)及肿瘤最长径等临床病理特征与淋巴结转移之间的关系。方法对2008年6月—2014年6月行手术治疗的376例ESCC患者的临床及病理资料进行了回顾性分析,比较肿瘤不同分化程度、浸润深度及不同最大径分组之间淋巴结转移情况的差异。结果随着肿瘤细胞分化程度的降低与浸润程度的加深,淋巴结转移阳性率显著升高(χ2=105.198及118.813,P<0.001),而肿瘤最长径≥3cm患者淋巴结转移率明显高于<3cm患者(χ2=88.289,P<0.001)。结论 ESCC的分化程度、浸润深度及肿瘤最长径与淋巴结阳性转移率呈正相关,在ESCC的临床分期及预后判断方面起重要作用。
Objective To investigate the relationship between the clinicopathologic features and lymph node metastasis of esophageal squamous cell carcinoma (ESCC), such as cell differentiation, depth of invasion (T stage) and longest tumor diameter. Methods The clinical and pathological data of 376 ESCC patients who underwent surgical treatment from June 2008 to June 2014 were retrospectively analyzed. The differences of tumor differentiation, depth of invasion and lymph node metastasis between different maximum diameter groups were compared . Results The positive rate of lymph node metastasis was significantly higher with the degree of differentiation and depth of invasion (χ2 = 105.198 and 118.813, P <0.001), while the lymph node metastasis rate was significantly higher than <3 cm Patients (χ2 = 88.289, P <0.001). Conclusion The degree of differentiation, the depth of invasion and the longest diameter of tumor are positively correlated with the positive rate of lymph node metastasis. It plays an important role in the clinical stage and prognosis of ESCC.