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目的:检测腺样囊性癌中细胞外基质金属蛋白酶诱导因子(Extracellular matrix metalloproteinase inducer,EMMPRIN)的表达和微血管密度(Microvessel density,MVD),探讨EMMPRIN和MVD在腺样囊性癌侵袭性方面的生物学作用机理。方法:用SP免疫组化法检测28例多形性腺瘤,33例腺样囊性癌中EMMPRIN的表达和MVD值。采用SPSS 10.0统计软件进行两样本间率的χ2检验和两组之间样本均数的t检验。结果:EMMPRIN在多形性腺瘤、腺样囊性癌的表达阳性率分别为53.71%、90.91%(P<0.05)。腺样囊性癌的MVD值高于多形性腺瘤。腺样囊性癌嗜神经现象组中EMMPRIN表达的阳性率和MVD值高于无嗜神经现象组,但差异不具有统计学意义。结论:EMMPRIN的表达和微血管密度与腺样囊性癌侵袭性的生物学行为密切相关。
AIM: To investigate the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) and microvessel density (MVD) in adenoid cystic carcinoma and to explore the role of EMMPRIN and MVD in the invasiveness of adenoid cystic carcinoma Biological mechanism of action. Methods: SP immunohistochemical method was used to detect the expression of EMMPRIN and MVD in 28 cases of pleomorphic adenoma and 33 cases of adenoid cystic carcinoma. SPSS 10.0 statistical software was used to test the χ2 test between the two samples and the t test between the two groups. Results: The positive rates of EMMPRIN in pleomorphic adenoma and adenoid cystic carcinoma were 53.71% and 90.91%, respectively (P <0.05). Adenoid cystic carcinomas have a higher MVD than pleomorphic adenomas. The positive rate and MVD of EMMPRIN expression in adenoid cystic carcinoma group were higher than those without neuropathic group, but the difference was not statistically significant. Conclusion: The expression of EMMPRIN and the microvessel density are closely related to the invasive biological behavior of adenoid cystic carcinoma.