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鼻黏膜含大量血管及腺体,又是整个机体黏膜免疫系统——黏膜相关淋巴样组织的主要部位之一,这种特点使其成为一精细、敏感和活跃的终末器官。变应性鼻炎(allergic rhinitis,AR)是鼻黏膜的一种变态反应性炎症[1]。从免疫学角度来看,AR是一系列细胞间相互作用,最终导致Th2>Th1反应。“变态反应中的Th2假说”认为,Th2细胞可以释放重要的细胞因子(GM-CSF、IL-4、IL-5、IL-6、IL-13)及趋化因子(巨噬细胞源趋化因子),在AR发病机制中起到举足轻重的作用[2]。AR患病率在全世界范围内日益升高,但治疗效果仍不尽人意,它可发生于任何年龄,社会负担巨大。
Nasal mucosa contains a large number of blood vessels and glands, but also the entire body mucosal immune system - one of the main parts of mucosa-associated lymphoid tissue, this feature makes it a fine, sensitive and active terminal organ. Allergic rhinitis (AR) is an allergic nasal inflammation [1]. From an immunological point of view, AR is a series of cell-cell interactions that ultimately result in a Th2> Th1 response. “The Th2 Hypersensitivity” suggests that Th2 cells release important cytokines (GM-CSF, IL-4, IL-5, IL-6, IL-13) and chemokines Chemokines), play an important role in the pathogenesis of AR [2]. AR prevalence in the world increasing, but the treatment effect is still unsatisfactory, it can occur at any age, a huge social burden.