越来越多的证据表明,子宫内膜异位症患者与正常人子宫内膜存在许多不同之处,表现为内异症患者的子宫内膜细胞粘附、侵袭和血管形成能力明显增强,使之具有异位种植和生长的能力,在内异症的发生和发展中起重要作用。最近研究表明,子宫内膜细胞自发性凋亡减弱和对凋亡信号不敏感,可能是内膜细胞具有异位种植和生长能力的重要因素。现就细胞凋亡在正常子宫内膜周期变化中的作用,以及对子宫内膜异位症发生发展的影响作以综述。 There is a growing body of evidence that there are many differences between endometriosis and normal endometrium in patients with endometriosis, as evidenced by a marked increase in endometrial cell adhesion, invasion and angiogenesis, It has the ability of ectopic planting and growth and plays an important role in the occurrence and development of endometriosis. Recent studies have shown that endometrial cells spontaneous apoptosis and apoptosis signal is not sensitive, may be intima cells with ectopic implantation and growth ability of an important factor. Now the role of apoptosis in the normal endometrial cycle, as well as the impact of the development of endometriosis are reviewed.