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目的:观察肝气郁结证整体水平上脑功能变化的特点,获得肝气郁结证中枢病变的定位信息。方法:采用配对研究的原则,应用正电子发射断层扫描成像技术,选择典型肝气郁结证患者60例,应用SPM图像分析软件,对比分析肝气郁结证与正常志愿者脑功能影像学的不同。结果:左侧额下回(BA47)、扣带回前部、扣带回后部、颞中回(BA21)、额中回(BA6)、双侧颞上回(BA37,38)、中央前回(BA4,6)等表现为葡萄糖低代谢状态(P<0.01);脑干中脑、延桥交界、右侧楔叶(BA18)、左侧小脑表现为葡萄糖高代谢状态(P<0.01)。结论:肝气郁结证相关脑区多呈现葡萄糖利用率降低,整体水平上为中枢参与肝气郁结证病变提供了客观的可视性影像学依据。
Objective: To observe the characteristics of the changes of brain function on the overall level of liver-qi stagnation syndrome and obtain the localization information of central lesion of liver-qi stagnation. Methods: According to the principle of paired study, 60 patients with typical liver-qi stagnation syndrome were selected by positron emission tomography. SPM image analysis software was used to analyze the difference of brain function imaging between the patients with liver-qi stagnation syndrome and normal volunteers. Results: Left inferior frontal gyrus (BA47), anterior cingulate gyrus, posterior cingulate gyrus, BA21, BA6, BA37, 38, (BA4,6) showed low metabolic state of glucose (P <0.01). Brain stem, midbrain junction and right wedge leaflet (BA18) and left cerebellum showed high glucose metabolism (P <0.01). Conclusion: The brain regions associated with liver-qi stagnation syndrome mostly show the decrease of glucose utilization, and provide objective visual evidence for the central involvement of liver-qi stagnation syndrome in imaging.