血小板源生长因子是成纤维细胞、平滑肌细胞及其他间充质来源细胞的强有丝分裂原和化学驱动剂。近年来的研究表明,在动脉粥样斑块发展过程中,血小板源生长因子及血小板源生长因子受体的作用可能尤其重要。文章对血小板源生长因子及其受体的结构、特点、作用和与动脉粥样硬化的病理关系作了简要归纳,以期为更好理解动脉粥样硬化的过程和探索如何防止其发生提供参考。 Platelet-derived growth factor is a mitogen and a chemical driver of fibroblasts, smooth muscle cells and other mesenchymal-derived cells. Recent studies have shown that the role of platelet-derived growth factor and platelet-derived growth factor receptors may be of particular importance during the development of atherosclerotic plaques. The article briefly summarized the structure, characteristics, roles of platelet-derived growth factor and its receptors and the pathological relationship with atherosclerosis in order to provide a reference for better understanding the process of atherosclerosis and exploring how to prevent it.