目的:通过实验论证临床配药后混合药液的内毒素是否迭加。方法:对医院常用的3个静脉配液处方配制后的混合液体,均用标示灵敏度为0.25 Eu.mL-1的鲎试剂,进行细菌内毒检查实验。结果:3个处方配伍后的液体,细菌内毒素限量实验均未出现阳性,结果无差异。结论:以大溶量注射剂(大输液)作为药物的溶媒或载体的药物配伍,小溶量注射剂的加入所考虑引起的内毒素迭加的理论,无实验支持数据,可以考虑几乎无迭加。 Objective: To verify whether the endotoxin in the mixed medicinal solution after clinical drug dispensing is superposed by experiments. Methods: The mixed liquid, which was prepared by intravenous infusion of 3 intravenous fluids commonly used in hospitals, was tested for bacterial endotoxemia by using 鲎 reagent with a labeling sensitivity of 0.25 Eu.mL-1. Results: The liquid and bacterial endotoxin limit test did not show any positive result after three prescriptions compatibility, the result was no difference. CONCLUSIONS: There is no experimental support data for the combination of drug compatibility with large-volume injection (large infusion) as vehicle or vehicle for drug delivery, and the addition of small-dose injections due to consideration of endotoxin superposition. Consider little overlap.