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目的:对比一清软胶囊与一清胶囊溶出度,进而评价一清软胶囊生物利用度。方法:以0.54%十二烷基磺酸钠(SDS)为溶剂,采用中国药典2005年版溶出度测定法第二法对一清软胶囊和一清胶囊的溶出度进行测定,以高效液色谱法对其中的黄芩苷进行测定。结果:一清软胶囊和一清胶囊的溶出度分别为97.5%,74.0%。结论:以0.54%SDS为溶剂,采用溶出度测定法第二法可测定软胶囊溶出度,一清软胶囊的溶出度明显好于一清胶囊。
Objective: To compare the dissolution of Yiqing soft capsule and Yiqing capsule and evaluate the bioavailability of Yiqing soft capsule. Methods: The dissolution rate of Yiqing Soft Capsule and Yiqing Capsule was determined by using 0.54% sodium dodecylsulfate (SDS) as solvent and the second method of dissolution test of Chinese Pharmacopoeia 2005 edition was used for high performance liquid chromatography. The baicalin was measured. Results: The dissolution of Yiqing Capsule and Yiqing Capsule was 97.5% and 74.0%, respectively. Conclusion: Using 0.54% SDS as solvent, the dissolution rate of soft capsules can be measured by dissolution method. The dissolution of Yiqing soft capsules is obviously better than that of Yiqing capsules.