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目的探讨血清C反应蛋白(C-RP)、外周血白细胞(WBC)与妊娠糖尿病(GDM)的关系。方法观察比较36例GDM(GDM组)、32例OGTT正常的孕妇(NGT组)和22例健康的非妊娠妇女(NC组)的血清C-RP、WBC、就诊时的BMI、糖脂代谢指标、HOMA-IR情况。结果与NC组相比,GDM组、NGT组的WBC、C-RP、HOMA-IR均增高(P<0.01),与NGT组相比,GDM组增高更明显(P<0.01)。C-RP和WBC均与就诊时BMI、TG、2hPG、2hIns、HOMA-IR呈正相关(P<0.01)。结论GDM的发生可能是由于母体肥胖导致炎症反应,加重IR,从而引起糖脂代谢紊乱。
Objective To investigate the relationship between serum C-reactive protein (C-RP), peripheral blood leukocytes (WBC) and gestational diabetes mellitus (GDM). Methods The serum C-RP, WBC, BMI, glucose and lipid metabolism index of 36 cases of GDM (GDM group), 32 normal pregnant women with NGTT (NGT group) and 22 healthy non-pregnant women (NC group) , HOMA-IR situation. Results Compared with NC group, WBC, C-RP and HOMA-IR of NGT group were significantly increased (P <0.01). Compared with NGT group, GDM group increased significantly (P <0.01). C-RP and WBC were positively correlated with BMI, TG, 2hPG, 2hIns and HOMA-IR at the time of visit (P <0.01). Conclusions The occurrence of GDM may be due to maternal obesity leading to inflammatory reaction and aggravating IR, which may lead to disorder of glucose and lipid metabolism.