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目的 :研究胃灵颗粒对大鼠乙酸慢性胃溃疡愈合质量的影响。方法 :用冰醋酸制备大鼠乙酸慢性胃溃疡模型 ,随机分为 5组 ,分别灌服蒸馏水 ,雷尼替丁 ,低、中、高剂量胃灵颗粒 ,用苏木精 -伊红染色对大鼠愈合性胃溃疡再生粘膜进行定量观察 ,并测胃壁结合粘液量、胃酸、胃蛋白酶活性。结果 :胃灵颗粒组改善胃粘膜的组织损伤 ,并提高胃壁结合粘液量 ,减少胃酸的排出。结论 :胃灵颗粒能提高溃疡愈合质量 ,是临床抗消化性溃疡复发的可能机制之一。
Objective: To study the effect of Weiling Granule on the healing quality of chronic gastric ulcer in rats. METHODS: A rat model of chronic acetic acid gastric ulcer was prepared with glacial acetic acid and randomly divided into 5 groups. Each group was given distilled water, ranitidine, low-, medium-, and high-dose Wei Ling granules. Hematoxylin-eosin staining was used for large rats. Quantitative observation was performed on murine reconstituted gastric ulcer regenerative mucosa, and the amount of gastric mucus bound, gastric acid, and pepsin activity were measured. Results: The Weiling Granule group improved the tissue damage of the gastric mucosa, increased the amount of mucin binding in the stomach wall, and reduced the excretion of gastric acid. Conclusion : Weiling granule can improve the quality of ulcer healing and is one of the possible mechanisms of clinical recurrence of peptic ulcer resistance.