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目的探讨恶性肿瘤患者外周血有核红细胞对伴发贫血及凝血功能异常的诊断意义。方法选取我院就诊44例外周血NRBC阳性的恶性肿瘤患者作为实验组及22例良性疾病患者作为对照组,釆用Sysmex XN-1000全自动血细胞分析仪检测患者外周血红细胞数(RBC)、血红蛋白(HB),釆用Sysmex CA-7000全自动血凝仪,检测凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)、D-二聚体(D-D),并对两组间各项指标进行统计学分析。结果恶性肿瘤患者组RBC、HB、APTT、FIB、D-D与正常对照组相比较,差异有统计学意义(P<0.05);PT、TT在两组间的差异无统计学意义。恶性肿瘤患者数据相关性分析,NRBC与RBC、HB、FIB、D-D、APTT之间存在明显相关性(P<0.05)。结论恶性肿瘤患者外周血NRBC与贫血和凝血指标的改变具有明显的相关性,NRBC可辅助用于临床对恶性肿瘤患者贫血和凝血异常状态的监测。
Objective To investigate the diagnostic value of peripheral blood erythrocytes in patients with malignant tumor for anemia associated with anemia and coagulation dysfunction. Methods Forty-four patients with NRBC-positive malignant tumors in our hospital were selected as the experimental group and 22 patients with benign disease as the control group. The peripheral blood red blood cell count (RBC), hemoglobin (HB), Sysmex CA-7000 automatic coagulation analyzer, prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen - dimer (DD), and statistical analysis of the indicators between the two groups. Results There were significant differences in RBC, HB, APTT, FIB and D-D between the two groups (P <0.05). The differences of PT and TT between the two groups were not statistically significant. There was a significant correlation between NRBC and RBC, HB, FIB, D-D and APTT in malignant tumor patients (P <0.05). Conclusion NRBC in peripheral blood of patients with malignant tumor has obvious correlation with changes of anemia and coagulation index. NRBC can be used to monitor anemia and coagulation abnormalities in patients with malignant tumor.