[Objective]To study the effects of polysaccharides from Tremella aurantialba mycelium(TMP) on the blood glucose and glucose tolerance of diabetic mice induced by alloxan.[Method]Kunming female mice were selected.Diabetic mice induced by alloxan were randomly divided into four groups,which were low-dose group(50 mg /kg),middle-dose group(100 mg /kg),high-dose group(150 mg /kg) and diabetic model control group.And the normal control group was also established.After fed with polysaccharides in Tremella aurantialba mycelium(TMP) by intragastric administration for 28 d,effects of polysaccharides on the blood glucose and glucose tolerance of diabetic mice were studied.[Result]Compared with model group,the body weight of low-,middle-and high-dose groups increased significantly(P < 0.05).The serum glucose value of high-dose group decreased obviously by 15.4%(P <0.05).In glucose tolerance determination,compared with model control group,the values of serum glucose after fed with glucose for 0.5 and 2 h were reduced by 9.4%(P <0.05) and 12.8%(P <0.05) respectively.The area udner glucose curve declined by 10.3%(P <0.05).[Conclusion]Polysaccharides from Tremella aurantialba mycelium with the concentration of 150 mg /kg had obvious hypoglycemic activity and could enhance the glucose tolerance of diabetic mice.T Polysaccharides from Tremella aurantialba mycelium with the concentrations of 50,100 and 150 mg /kg could slow down the body weight decrease of diabetic mice. [Objective] To study the effects of polysaccharides from Tremella aurantialba mycelium (TMP) on the blood glucose and glucose tolerance of diabetic mice induced by alloxan. [Method] Kunming female mice were selected. Diabetic mice induced by alloxan were randomly divided into four groups , which were low-dose group (50 mg / kg), middle-dose group (100 mg / kg), high-dose group After fed with polysaccharides in Tremella aurantialba mycelium (TMP) by intragastric administration for 28 d, effects of polysaccharides on the blood glucose and glucose tolerance of diabetic mice were studied. [Result] Compared with model group, the body weight of low-, middle -and high-dose groups were significantly (P <0.05). The serum glucose value of high-dose group significantly obviously decreased by 15.4% (P <0.05) .In glucose tolerance determination, compared with model control group, the values ​​of serum glucose after fed with glucose for 0.5 Conclusion The udner glucose curve declined by 10.3% (P <0.05). [Conclusion] Polysaccharides from Tremella aurantialba mycelium with the concentration of 150 mg / kg had obvious hypoglycemic activity and could enhance the glucose tolerance of diabetic mice. Polysaccharides from Tremella aurantialba mycelium with the concentrations of 50, 100 and 150 mg / kg could slow down the body weight decrease of diabetic mice.