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N-myc下游调节基因(N-myc downstream regulated gene,NDRG)家族由NDRG1-4 4个成员组成,相互之间具有很高的氨基酸同源性。NDRG家族成员在不同物种间表达具有高度保守性,而在不同组织间分布有较大差异。近年来,研究发现NDRG家族成员在多种肿瘤中表达异常,并与肿瘤进展和预后相关,是潜在的肿瘤诊断、预后评价标志物和治疗靶标。
The N-myc downstream regulated gene (NDRG) family consists of 4 members of NDRG1-4, which have high amino acid homology with each other. The members of NDRG family are highly conserved among different species, while they are widely distributed among different species. In recent years, the study found that NDRG family members in a variety of tumors abnormal expression, and tumor progression and prognosis, is a potential tumor diagnosis, prognostic markers and treatment targets.