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目的 探讨影响鼻咽癌患者放射治疗后远期预后的因素。方法 选择首诊的鼻咽癌患者 13 5例 ,均予以根治性放射治疗 (放疗 ) ,照射剂量 68～ 80Gy/7～ 8周。分析 13项可能对鼻咽癌预后产生影响的因素 ,利用统计软件进行单因素及Cox回归模型多因素分析。结果 鼻咽癌 10年生存率为 48 9% ;在单因素分析的 13项中有 8项因素影响鼻咽癌的预后 (P <0 0 5 ) ;而多因素分析中仅有颅神经损伤、颅底骨质破坏及N分期为影响鼻咽癌独立的预后因素。结论 鼻咽癌伴有颅神经损伤和 /或颅底骨质破坏和 /或颈部较大肿块者预后不良 ,对此类病例需进行综合治疗 ,以减少肿瘤的复发及转移 ,提高治疗的疗效
Objective To explore the factors influencing long-term prognosis of patients with nasopharyngeal carcinoma after radiotherapy. Methods Thirteen patients with nasopharyngeal carcinoma (NPC) were chosen as the first diagnosis, all undergoing radical radiotherapy (radiotherapy) at doses of 68-80 Gy / 7-8 weeks. Thirteen factors that may affect the prognosis of NPC were analyzed. Statistical software was used to perform multivariate analysis of single factor and Cox regression model. Results The 10-year survival rate of nasopharyngeal carcinoma was 48.9%. Eight of the 13 items of single factor analysis affected the prognosis of nasopharyngeal carcinoma (P <0.05), while the multivariate analysis showed only cranial nerve injury, The skull base bone destruction and N stage were independent prognostic factors of nasopharyngeal carcinoma. Conclusions The prognosis of nasopharyngeal carcinoma with cranial nerve injury and / or skull base bone destruction and / or larger neck mass is poor. Comprehensive treatment of such cases is needed to reduce the recurrence and metastasis of the tumor and improve the curative effect