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回顾分析顺行性溶栓治疗20例晚期恶性肿瘤并发深静脉血栓形成(Trousseau综合征)患者的临床资料。18例以恶性肿瘤首诊入院,围手术期发生DVT;2例以DVT首诊入院,经影像学检查发现腹膜后恶性肿瘤。深静脉血栓形成经彩色多普勒外周血管超声检查确诊。采用尿激酶顺行性溶栓,同时全身应用低分子右旋糖苷,低分子肝素钠皮下注射服用小剂量肠溶阿司匹林及中医中药等措施治疗。本组无围手术期死亡病例。1例因疗效果不明显而放弃治疗自动出院;其余19例均获不同程度缓解,获临床治愈效果。提示对于原因不明的DVT,应疑及Trousseau综合征的可能;顺行性溶栓治疗效果可靠。
The clinical data of 20 patients with advanced malignant tumor complicated with deep venous thrombosis (Trousseau’s syndrome) undergoing thrombolytic therapy were retrospectively analyzed. Eighteen patients were admitted to hospital with malignant tumors, and perioperative DVT occurred. Two patients were admitted to hospital with DVT first, and retroperitoneal malignant tumors were found by imaging examination. Deep venous thrombosis was confirmed by color Doppler ultrasonography of peripheral blood vessels. Urokinase with thrombolytic therapy, systemic low molecular weight dextran, low molecular weight heparin sodium subcutaneous injection of small doses of enteric-coated aspirin and traditional Chinese medicine and other measures. This group no perioperative deaths. 1 case of treatment was not obvious and give up the treatment of spontaneous discharge; the remaining 19 cases were relieved in varying degrees, the clinical cure. Tip For unexplained DVT, Trousseau syndrome should be suspected and the possibility of antegrade thrombolytic therapy is reliable.