抗癌药的腹腔内应用很早就已进行,但直到近年来才真正认识到其价值。1988年2月在美国圣地亚哥市召开的第2届腔内化疗的国际会议上,腹腔内给药作为积极的治疗方法已被公认。人们期待着腹腔内给药法能作为与经动脉和经静脉法并列的给药方法之一。腹腔内给药法的目的在于①治疗癌性腹腔炎;②预防由腹腔内消化系统癌及卵巢、子宫癌等手术中脱落细胞引起癌复发,同时治疗位于腹膜上的微小癌;③用于全身给药尤其是向门脉系统高浓度的给药。腹腔内给药法的特征是:1.可在腹腔内高浓度地应用抗癌药,即具有使药物充分接触肿瘤的药物动力学优点;2.通过腹腔内给药,抗癌药可迅速吸收,分子量大于1000以上者可经淋巴系统吸收,进入全身循环。等张液在给药后最初一小时里吸收最快,此后逐渐减 The intraperitoneal application of anti-cancer drugs has been carried out very early, but it has not really recognized its value until recently. At the 2nd International Conference on Endovascular Chemotherapy held in San Diego, USA in February 1988, intraperitoneal administration has been recognized as an active treatment method. It is expected that intraperitoneal administration can be used as one of the methods of administration in parallel with transarterial and transvenous methods. The purpose of the intraperitoneal administration method is to treat cancerous abdominal inflammation; 2 to prevent cancer recurrence caused by intra-abdominal digestive system cancer and ovary, uterine cancer and other surgical exfoliated cells, and to treat micrometastasis in the peritoneum; 3 for whole body In particular, the administration is a high concentration of administration to the portal system. The intraperitoneal administration method is characterized by: 1. The anticancer drug can be applied at high concentration in the abdominal cavity, that is, having the pharmacokinetic advantage of making the drug sufficiently contact with the tumor; 2. The anticancer drug can be rapidly absorbed through the intraperitoneal administration. , molecular weight greater than 1000 or more can be absorbed through the lymphatic system into the systemic circulation. Isotonic fluid absorbed the fastest in the first hour after administration and gradually decreased thereafter