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目的:观察尼莫同在高血压性脑出血急性期的疗效。方法:将96例经头颅CT证实为基底节脑出血患者(诊断为高血压性脑出血)随机分为观察组与对照组,各48例,两组患者均给与甘露醇脱水降颅压,降压药物控制血压,保护脑组织及对症治疗,同时静脉补液,防止水电解质紊乱,预防感染及应激性溃疡,观察组加用尼莫同10 mg/50 ml以3～4 mg/h缓慢静滴,bid,共治疗14天,治疗前后比较2组血肿体积、水肿面积、NIHSS评分及BI评分。结果:尼莫同治疗组较对照组明显缩小水肿面积、降低NIHSS评分、增加BI评分,但血肿体积无明显改变。结论:尼莫同治疗高血压性脑出血在短期内不增加血肿体积,明显出血后水肿面积,从而改善临床症状,促进神经功能缺失的恢复。
Objective: To observe the effect of nimodipine in acute stage of hypertensive intracerebral hemorrhage. Methods: Ninety-six patients with cerebral hemorrhage confirmed by skull CT were diagnosed as hypertensive intracerebral hemorrhage. The patients were randomly divided into observation group and control group, 48 cases in each group. Both groups were given intracranial pressure with mannitol dehydration, Antihypertensive drugs to control blood pressure, brain tissue protection and symptomatic treatment, while intravenous rehydration, to prevent water and electrolyte disorders, prevention of infection and stress ulcer, the observation group plus nimotone 10 mg / 50 ml with 3 ~ 4 mg / h slow Intravenous, bid, a total of 14 days treatment, before and after treatment compared two groups of hematoma volume, edema area, NIHSS score and BI score. Results: Compared with the control group, the nimotoponin treatment group significantly reduced the area of edema, decreased the NIHSS score and increased the BI score, but the volume of hematoma volume did not change significantly. Conclusion: Nimodipine treatment of hypertensive cerebral hemorrhage in the short term does not increase the volume of hematoma, hemorrhage after the apparent hemorrhage area, thereby improving clinical symptoms and promote the recovery of neurological deficits.