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目的比较左氧氟沙星与甲硝唑(联合奥美拉唑、阿莫西林)三联疗法治疗幽门螺杆菌(Hp)相关性胃炎的疗效及安全性。方法80例经胃镜检查证实为Hp相关性胃炎患者,随机分为治疗组和对照组各40例,治疗组采用盐酸左氧氟沙星片800 mg/d,对照组采用甲硝唑片400 mg/d,两组均联合阿莫西林分散片2 000mg/d,奥美拉唑肠溶片40mg/d,上述药物剂量均分2次口服,连续用药7 d。7 d后两组继续口服奥美拉唑肠溶片40 mg/d至1个月。治疗前后作胃镜检查及Hp检测,观察2组的疗效、Hp根除率及药物不良反应情况。结果两组总有效率比较差异有统计学意义(P<0.05);两组Hp根除率比较差异有统计学意义(P<0.05);2组不良反应发生率比较差异有统计学意义(P<0.05)。结论左氧氟沙星联合奥美拉唑、阿莫西林三联疗法治疗Hp相关性胃炎的疗效优于甲硝唑联合奥美拉唑、阿莫西林三联疗法,且不良反应少。
Objective To compare the efficacy and safety of triple therapy with levofloxacin and metronidazole (combined with omeprazole and amoxicillin) in the treatment of Helicobacter pylori-associated gastritis. Methods Eighty patients with Hp-related gastritis confirmed by gastroscopy were randomly divided into treatment group (40 cases) and control group (n = 40), levofloxacin hydrochloride tablets (800 mg / d) and metronidazole tablets Group were combined amoxicillin dispersible tablets 2 000mg / o, omeprazole enteric-coated tablets 40mg / d, the drug dose was divided into 2 oral, continuous medication for 7 days. After 7 days, the two groups continued oral omeprazole enteric-coated tablets 40 mg / d to 1 month. Before and after treatment for gastroscopy and Hp test to observe the efficacy of two groups, Hp eradication rate and adverse drug reactions. Results There was significant difference in the total effective rate between the two groups (P <0.05). There was significant difference between the two groups in the eradication rate of Hp (P <0.05). There was significant difference in the incidence of adverse reactions between the two groups (P < 0.05). Conclusion Levofloxacin combined with omeprazole and amoxicillin triple therapy is superior to metronidazole combined with omeprazole and amoxicillin triple therapy in the treatment of Hp-related gastritis with less adverse reactions.