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肾病综合征出血热(Hemorrhagic fever with renalsyndromes,HFRS)旧称流行性出血热(Epidemic hemor-rhagic fever,EHF).是一种常引起急性肾功能衰竭的急性传染病,出血是HFRS的主要临床表现之一,引起HFRS患者出血的机制迄今仍在探索之中.为了解HFRS患者血浆纤溶酶(PL)的活性变化及其与临床出血症状等表现的关系,我们用发色底物法检测了50例HFRS患者病程中各期血浆PL的活性,结果发现HFRS患者自发热期开始血浆PL活性即明显增强,至多尿期仍高于正常,PL的活性与患者出血症状、肾功能损害等有一定联系,现将有关资料报道如下.
Hemorrhagic fever with renalsyndromes (HFRS), formerly known as Epidemic hemor-rhagic fever (EHF), is an acute infectious disease that often causes acute renal failure. Bleeding is the major clinical manifestation of HFRS First, the mechanism of bleeding caused by HFRS patients is still being explored.To understand the changes of plasma fibrinolytic enzyme (PL) in patients with HFRS and its relationship with the clinical manifestations of bleeding, we used the chromogenic substrate assay 50 Cases of HFRS patients with various stages of plasma PL activity in the course of HFRS patients found that plasma PL activity from the onset of fever that was significantly higher than the normal to the polyuria, PL activity and bleeding symptoms in patients with renal dysfunction are related Now the relevant information is reported below.