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目的:分析卡前列素氨丁三醇联合缩宫素对高危妊娠产妇剖宫产后出血的效果。方法:研究选取2015年3月到2015年12月浙江省绍兴市中心医院收治的进行剖宫产并且具有高危妊娠的产妇120例。将入组患者随机分为两组,观察组和对照组各60例患者,入组的120例产妇均在麻醉后(连续硬膜外)在子宫下段进行剖宫产手术。对照组患者在胎儿娩出之后给予缩宫素,观察组患者在胎儿娩出之后给予卡前列素氨丁三醇联合缩宫素治疗。结果:该次研究对两组产妇在分娩时以及分娩后接受药物治疗后的各项APTT、TT、Fg以及BPC常规检测进行观察比较,分娩时两组孕妇的常规凝血指标均无差异(P>0.05),分娩后72h分别接受各自治疗后两组各项指标均有所好转,但是观察组患者明显优于对照组患者(P<0.05)。观察组患者在术中、术后2h、术后24h出血量分别为(105.34±12.43)ml、(126.35±11.58)ml、(221.31±13.31)ml,明显低于对照组产妇在各个阶段内的出血量(P<0.05);观察组产妇在手术结束后24h内的尿量为(1 521.31±289.53)ml,明显高于对照组产妇(1 031.97±201.31),P<0.05。该次研究两组患者接受治疗后出现的不良反应主要有腹泻、发热、恶心、血压升高等,观察组产妇没有出现腹泻情况,出现了1例发热患者,2例恶心患者,1例血压升高患者,总的不良反应率为6.67%;对照组产妇出现了发热和腹泻患者各1例,3例恶心患者,没有出现血压升高患者,总的不良反应率为8.33%,两组相比差异无统计学意义(P>0.05)。结论:卡前列素氨丁三醇联合缩宫素对患者的疗效确切,能显著提高术后愈合,降低产后出血量与缩短出血时间,同时降低术后引发的相关并发症,在临床上具有十分重要的意义。
OBJECTIVE: To analyze the effect of carboprost trometamol combined with oxytocin on postpartum hemorrhage in high-risk pregnant women. Methods: From March 2015 to December 2015, 120 women with cesarean section and high-risk pregnancy admitted to Shaoxing Central Hospital of Zhejiang Province were selected. The patients were randomly divided into two groups, the observation group and the control group of 60 patients, each group of 120 maternal anesthesia (continuous epidural) cesarean section in the lower uterine segment. Patients in the control group were given oxytocin after the fetus was delivered and patients in the observation group were treated with carboprost and oxytocin after the fetus was delivered. Results: The study compared the routine testing of APTT, TT, Fg and BPC between the two groups during labor and after delivery. There was no difference in routine coagulation indexes between the two groups during delivery (P> 0.05). After 72 hours after delivery, the indexes of both groups improved after treatment. However, the observation group was significantly better than the control group (P <0.05). The blood loss in the observation group was (105.34 ± 12.43) ml, (126.35 ± 11.58) ml and (221.31 ± 13.31) ml respectively at 2 h and 2 h after operation, which was significantly lower than that in the control group (P <0.05). The urine output of the observation group within 24 hours after the surgery was (5221.31 ± 289.53) ml, which was significantly higher than that of the control group (1031.97 ± 201.31), P <0.05. In this study, two groups of patients received treatment of adverse reactions are mainly diarrhea, fever, nausea, blood pressure, the observation group maternal no diarrhea, there was 1 case of fever, nausea in 2 patients, 1 case of hypertension Patients, the total adverse reaction rate was 6.67%; control group maternal fever and diarrhea in 1 case, 3 patients with nausea, no blood pressure in patients with a total adverse reaction rate of 8.33%, the difference between the two groups No statistical significance (P> 0.05). Conclusion: Carduvastatin trometamol and oxytocin in patients with curative effect is exact, can significantly improve postoperative healing, reduce the amount of postpartum hemorrhage and shorten the bleeding time, while reducing the postoperative complications caused by the clinically significant Significance.