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目的 :观察急性冠状动脉综合征 (ACS)发病时炎性趋化因子的作用 ,探讨ACS发病机制。方法 :选取ACS患者 80例 ,其中急性心肌梗死 (AMI) 4 0例 ,不稳定型心绞痛 (UAP) 4 0例。ACS患者经治疗 4个月后进行随访。同时选取正常对照 4 0例。采用酶联免疫法测定上述病例和对照者血清中的巨噬细胞趋化蛋白 1(MCP 1)、白细胞介素 8(IL 8)水平 ,并进行统计学分析。结果 :AMI组、UAP组MCP 1显著高于对照组 ,并在随访时明显降低 ,而IL 8水平无明显差异。结论 :外周血中MCP 1水平可以作为诊断和预测ACS发生的敏感指标 ,并可以反映病情的稳定情况 ,在临床工作中有一定的应用价值
Objective: To observe the role of inflammatory chemokines in the pathogenesis of acute coronary syndrome (ACS) and to explore the pathogenesis of ACS. Methods: Eighty ACS patients were selected, including 40 cases of acute myocardial infarction (AMI) and 40 cases of unstable angina pectoris (UAP). ACS patients were followed up for 4 months after treatment. At the same time select the normal control 40 cases. Enzyme-linked immunosorbent assay was used to determine the levels of MCP-1, IL-8 in serum of the above cases and controls, and statistical analysis was performed. Results: The levels of MCP 1 in AMI group and UAP group were significantly higher than those in control group, and were significantly decreased at follow-up. There was no significant difference in IL 8 level. Conclusion: The level of MCP 1 in peripheral blood can be used as a sensitive indicator to diagnose and predict ACS, which can reflect the stable condition of disease and has certain value in clinical work