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目的:分析Paget病的临床及组织病理学特征。方法:回顾性分析14例Paget病患者的临床及病理资料。结果:男6例,女8例;平均年龄58±3.58岁;平均病程32.31±29.63个月。发生在龟头1例;腋下1例;乳房5例;阴囊5例,其中累及阴茎3例;女性外阴2例。11例患者皮损为红斑,伴有浸润、糜烂和结痂。3例患者仅为红斑,表面附有少量白色鳞屑。10例患者在疾病初期均误诊为湿疹。组织病理均具有典型的Paget细胞。免疫组化显示所有患者CK7均阳性、CK20阴性、EMA12例阳性,CEA13例阳性。所有患者均未并发其他肿瘤。结论:Paget病易误诊为湿疹,免疫组化检查具有辅助诊断价值。
Objective: To analyze the clinical and histopathological features of Paget’s disease. Methods: The clinical and pathological data of 14 cases of Paget’s disease were analyzed retrospectively. Results: There were 6 males and 8 females with an average age of 58 ± 3.58 years and a mean duration of 32.31 ± 29.63 months. Occurred in the glans 1 case; armpit 1 case; 5 cases of breast; scrotum in 5 cases, of which 3 cases involving the penis; female genital in 2 cases. Eleven patients had erythematous lesions with infiltration, erosion and crusting. Three patients had erythema only and a small amount of white scales attached to the surface. Ten patients were misdiagnosed as eczema early in the disease. Histopathology has typical Paget cells. Immunohistochemistry showed that all patients CK7 were positive, CK20 negative, EMA 12 cases were positive, CEA 13 cases were positive. None of the patients had other tumors. Conclusion: Paget disease is easily misdiagnosed as eczema, and immunohistochemistry has diagnostic value.