乙肝病毒感染已被认为是导致许多肝病发病的主要原因。但其致病机制复杂,目前为止尚未完全阐明。近年来,许多文献报道乙肝病毒Pre-S2的基因变异是导致乙肝相关性疾病发病的重要因素之一。本文就PreS2基因变异导致相关肝病发病的最新研究进展进行综述。 Hepatitis B virus infection has been considered the leading cause of many liver diseases. However, its pathogenic mechanism is complex and has not been fully elucidated so far. In recent years, many literatures reported that the gene mutation of HBV Pre-S2 is one of the important factors leading to the development of hepatitis B-related diseases. This review summarizes recent advances in the pathogenesis of related liver diseases caused by mutations in PreS2 gene.