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0 引言 细胞凋亡障碍与肿瘤细胞的多药耐药有关 .一些耐药细胞株表达较高水平的抗凋亡蛋白 Bcl-x L.我们将 bcl-x L基因转导入白血病细胞株 HL -60中 ,证实 bcl-x L 高表达可介导细胞耐药的形成[1 ] .用 PT-PCR法进一步检测 bcl-x基因在 1 6例急性髓系白血病 ( acute myeloid
0 Introduction Apoptosis is associated with multidrug resistance in tumor cells. Some drug-resistant cell lines express higher levels of the anti-apoptotic protein Bcl-x L. We transduced the bcl-x L gene into the leukemia cell line HL-60 , Confirmed that the high expression of bcl-x L can mediate the formation of cell resistance [1] by PT-PCR method for the further detection of bcl-x gene in 16 cases of acute myeloid leukemia (acute myeloid