Wijdicks和Jack报告了用纤维蛋白溶解法治疗冠状动脉闭塞后脑叶出血的8例病人,除1例外,余均短期内死亡,其中有1例患高血压。年龄最大的1例手术时充分暴露脑组织,观察到几条脑动脉大量沉淀嗜刚果红(congophilic)物质,血管中层和外膜有淀粉样蛋白。作者建议,在确定由纤维蛋白溶解治疗冠心病引起的脑内出血的病因方面,系统的神经病理学研究应集中在严重的淀粉样血管病上。在最近的一项人群调查中,Broderick等报告,发现致命和非致命的脑叶出血的主要危险因素还是高血压。在作者认识到高血压和淀粉样血管病不是彼此独立时,他们的研究证明,在全部脑内出血中,脑叶 Wijdicks and Jack reported 8 cases of fibrinolytic treatment of cerebral lobe hemorrhage after coronary occlusion, with the exception of one exception, all were short-term deaths, of which 1 case of hypertension. One of the oldest patients underwent surgery that fully exposed brain tissue. Several cerebral arteries were observed to precipitate large amounts of congophilic material with amyloid in the middle and outer vessels. The authors suggest that systematic neuropathological studies should focus on severe amyloid angiopathy in determining the cause of intracerebral hemorrhage due to fibrinolytic treatment of coronary heart disease. In a recent population survey, Broderick et al. Reported that the major risk factor for fatal and non-fatal lobar hemorrhage was hypertension. When the authors realized that hypertension and amyloid angiopathy were not independent of each other, their study demonstrated that in all intracerebral hemorrhage,