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目的探讨非小细胞肺癌组织中环氧化酶-2(COX-2)、表皮生长因子受体(EGFR)的表达及其临床意义。方法采用免疫组化SABC法检测58例非小细胞肺癌及9例癌远旁正常肺组织中COX-2、EGFR的表达水平。结果肺癌组织中COX-2、EGFR阳性表达分别为60.34%(35/58)、63.79%(37/58),明显高于癌远旁正常组织(11.11%,P<0.01);COX-2、EGFR表达与肺癌的TNM分期、淋巴结浸润显著相关(P<0.05),与肺癌患者的年龄、性别、吸烟状况、组织类型无关(P>0.05);COX-2、EGFR有相关表达(P<0.05),COX-2、EGFR阳性表达者预后不良(P<0.05)。结论COX-2、EGFR在肺癌的发展和转移中可能起作用,COX-2、EGFR可以作为肺癌的预后指标。
Objective To investigate the expression of cyclooxygenase-2 (COX-2) and epidermal growth factor receptor (EGFR) in non-small cell lung cancer and its clinical significance. Methods Immunohistochemical SABC method was used to detect the expression of COX-2 and EGFR in 58 cases of non-small cell lung cancer and 9 cases of normal lung cancer. Results The positive expressions of COX-2 and EGFR in lung cancer tissues were 60.34% (35/58) and 63.79% (37/58) respectively, which were significantly higher than those in normal tissues (11.11%, P <0.01) The expression of EGFR was correlated with the TNM stage and lymph node infiltration of lung cancer (P <0.05), but not with the age, sex, smoking status and type of lung cancer (P> 0.05) ), COX-2, EGFR positive expression of poor prognosis (P <0.05). Conclusions COX-2 and EGFR may play roles in the development and metastasis of lung cancer. COX-2 and EGFR may serve as prognostic indicators for lung cancer.