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目的探讨动脉粥样硬化性脑梗死患者血浆氧化低密度脂蛋白与血管内皮损伤及血小板活化程度的关系。方法用酶联免疫吸附测定(ELISA)的方法检测49例脑梗死患者和50例相匹配的对照组血浆氧化低密度脂蛋白(OX-LDL)、血管性假血友病因子(VWF)、血浆颗粒膜蛋白(GMP-140)水平,同时用硝酸还原酶比色法测定血清一氧化氮(NO)水平,并把VWF、GMP-140、NO与OX-LDL作相关分析。结果脑梗死组血浆OX-LDL、VWF、GMP-140明显高于对照组(t=2.91,P<0.01;t=3.94,P<0.001;t=2.08,P<0.05),而脑梗死组血清NO水平明显低于对照组(t=4.02,P<0.001);相关分析表明血浆OX-LDL水平与血清NO水平呈负相关(r=-0.204,P<0.05),与血浆VWF呈正相关(r=0.60,P<0.01),与血浆GMP-140呈正相关(r=0.430,P<0.01)。结论脑梗死患者的血浆OX-LDL明显增高,而OX-LDL增高可能是脑梗死的危险因素。
Objective To investigate the relationship between plasma oxidized low density lipoprotein (LDL), vascular endothelial damage and platelet activation in patients with atherosclerotic cerebral infarction. Methods The levels of plasma oxidized low density lipoprotein (OX-LDL), von Willebrand factor (VWF), plasma The level of GMP-140 was detected by enzyme-linked immunosorbent assay (ELISA). The level of serum nitric oxide (NO) was measured by nitrate reductase colorimetry. Correlation analysis of VWF, GMP-140, NO and OX- Results The levels of plasma OX-LDL, VWF and GMP-140 in cerebral infarction group were significantly higher than those in control group (t = 2.91, P <0.01; t = 3.94, P <0.001; The level of NO was significantly lower than that of the control group (t = 4.02, P <0.001). Correlation analysis showed that plasma OX-LDL level was negatively correlated with serum NO level (r = -0.204, = 0.60, P <0.01), and positively correlated with plasma GMP-140 (r = 0.430, P <0.01). Conclusion The plasma OX-LDL in patients with cerebral infarction is significantly increased, while the increased OX-LDL may be the risk factor of cerebral infarction.