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口服痢疾菌苗片预防痢疾已有50余年历史,认为具有一定效果。但由于痢疾病原体动态与型别的复杂,效果一般较低。根据苏联保健部1951年在全苏10大城市的23万儿童中的试验观察,免疫组与对照组痢疾发病率之比为1:1.2至1:2.18,我国1958年、1959年卫生部生物制品研究所等单位对北京市1,309、名儿童和18,000名居民中进行试验,免疫组与对照组痢疾发病率之比,分别为1:2.5和1:1.6,均认为有一定的效果。1960年我部进行了试验性现察,兹就其结果综述如下:一、菌苗及服法此次试验所采用的痢疾菌苗片系1960年2月2日武汉生物制品研究所出品;每片包含细菌1,000亿个,其中弗氏Ⅱ型40%、弗氏Ⅲ型30%、宋内氏菌30%。我们确定某分队为试验点,并确定2、3、5小队为免疫组,按计划进行口服菌苗片,同时采取综合性预防措施,但不投予任何其他防痢药品;1、4小队和
Oral dysentery vaccine tablets have been dysentery prevention for more than 50 years, with a certain effect. However, due to the dynamic and type of dysentery pathogens complex, the effect is generally low. According to the experimental observation of 230,000 children in the Soviet Union in 1951 in 10 cities of the Soviet Union, the incidence of dysentery between the immunized group and the control group was 1: 1.2 to 1: 2.18. In 1958 and 1959, the Ministry of Health’s biological products Institute and other units of Beijing 1,309, 18,000 children and children were tested, the incidence of dysentery immunization group and the control group were 1: 2.5 and 1: 1.6, all considered to have a certain effect. In 1960, I conducted a tentative investigation, the results of which are summarized as follows: First, the vaccine and service law The dysentery vaccine used in this test was February 2, 1960 Wuhan Institute of Biological Products produced; each The tablet contains 100 billion bacteria, of which 40% are Type 2, 30% are Type 3 and 30% are Neisseria. We identified a unit as a test site and identified cells 2, 3 and 5 as the immunized group. Oral vaccine tablets were planned and comprehensive preventive measures were taken at the same time, but no other anti-diarrhea drugs were administered; 1,4 and 4