The research progress on the development and application of new natural tobacco humectants was reviewed in the paper. Plants, animals and microbes contain special moisturizing substances, showing distinctive advantages and outstanding ef-fects in respect of the tobacco moisture content maintaining and cigarette suction comfort promoting. The development necessity, major types, functional mechanism and influence on cigarette quality of new natural tobacco humectants development were com-pared and elaborated. Additional y, the prospect of new natural tobacco humectants development and application was forecasted.