Objective To assess the factors that determine cosmetic results after periareolar excisional biopsy for the management of Breast Imaging-Reporting and Data System(BI-RADS)3 and 4 breast lesions.Methods Potential risk factors for adverse cosmetic results of incision after periareolar excisional biopsy were evaluated in 74 patients(7 people had bilateral breast operations)undergoing a single biopsy after suspicion of a malignant lesion that subsequently proved to be benign.The overall cosmetic result was evaluated using a modification of the European Organisation for Research and Treatment of Comcer(EORTC)cosmetic indices individually scored 6 months after the breast excisional biopsy.To evaluate the factors affecting cosmetic outcome of incision,an analysis of variance was undertaken using the Kruskal-Wallis test for continuous variables and the chi-squared and Fisher exact tests for categorical variables.Based on cosmetic outcome of incision as dependent variables,and patient’s age,incision location,scar color respectively as independent variables,multivariate analysis was performed with logistic regression for screening the factors.Results Out of 81operated breasts,the cosmetic result of incision was rated as excellent(0 score)in 19(23.46%),good(1 score)in 38(46.91%),fair(2 scores)in 14(17.28%),and poor(3 scores)in 10(12.34%).Univariate analysis shows that age,incision location and scar color affected cosmetic result.Older patients,with no scar or white scar,and the inferior or lateral periareolar incision had better cosmetic outcomes of incision.Patients more than 45 years had better cosmetic outcomes of incision than those less than 31 years(P=0.0231).Patients with the inferior or lateral periareolar incision obtained better cosmetic outcomes than those with the superior or medial incision.Patients with no scar obtained better cosmetic outcomes than those with white scar or red scar.Conclusions The cosmetic outcomes after periareolar excisional biopsy of benign breast lesions are excellent or good in most of cases.Age,incision location and scar color all affect cosmetic results of incision. Objective To assess the factors that determine cosmetic results after periareolar excisional biopsy for the management of Breast Imaging-Reporting and Data System (BI-RADS) 3 and 4 breast lesions. Methods Potential risk factors for adverse cosmetic results of incision after periareolar excisional biopsy were as in 74 patients (7 people had bilateral breast operations) undergoing a single biopsy after suspicion of a malignant lesion that sharps proved to be benign.The overall cosmetic result was evaluated using a modification of the European Organization for Research and Treatment of Comcer (EORTC ) cosmetic indices individually scored 6 months after the breast excisional biopsy. To evaluate the factors affecting cosmetic outcome of incision, an analysis of variance was undertaken using the Kruskal-Wallis test for continuous variables and the chi-squared and Fisher exact tests for categorical variables . Based on cosmetic outcome of incision as dependent variables, and patient’s age, i ncision location, scar color respectively as independent variables, multivariate analysis was performed with logistic regression for screening the factors. Results Out of 81operated breasts, the cosmetic result of incision was rated as excellent (0 score) in 19 (23.46%), good ( 1 score) in 38 (46.91%), fair (2 scores) in 14 (17.28%), and poor (3 scores) in 10 (12.34%). Univariate analysis shows that age, incision location and scar color affected cosmetic result. Older patients, with no scar or white scar, and the inferior or lateral periareolar incision had better cosmetic outcomes of incision. Patients more than 45 years had better cosmetic outcomes of incision than those less than 31 years (P = 0.0231). Patients with the inferior or lateral periareolar incision obtained better cosmetic outcomes than those with the superior or medial incision. Patients with no scar obtained better cosmetic outcomes than those with white scar or red scar.Conclusions The cosmetic outcomes after periareolar excisional biopsy of benign bbreast lesions are excellent or good in most of cases. Ange, incision location and scar color all affect cosmetic results of incision.