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腺苷用于阵发性室上性心动过速(PSVT)的治疗已逐渐被接受,该药已知的副作用常见的有面潮红、恶心、胸闷、头晕和轻度头痛。而头痛可能是低血压或脑血管扩张的后果。本文报道1例因静脉注射腺苷后引起颅内压(ICP)升高的病例。患者男性,58岁。因头部外伤后发生硬膜下血肿而住院治疗。手术前行ICP 监测,颅内压波动于1.5～2.0KPa之问持续4天,第四天因发生SVT 且伴血压降低而给予腺苷静脉注射治疗,剂量为50μg/kg/次;以后每2分钟增加50μg,直至总量达250μg/kg 时仍无效。同时发现每次用药后均引起平均动脉压(MAP)下降和ICP 升高,程度与剂量相关。剂量为150μg/kg 时,ICP 从早期的1.5～2.0KPa 上升至3.0～3.5KPa;剂
The use of adenosine for the treatment of paroxysmal supraventricular tachycardia (PSVT) has gradually been accepted and the known side effects of this drug are often flushing, nausea, chest tightness, dizziness, and mild headaches. Headache may be the result of hypotension or dilatation of the blood vessels. This article reports 1 case of intracranial pressure (ICP) caused by intravenous injection of adenosine increased cases. Male patient, 58 years old. Subdural hematoma due to head injury and hospitalization. ICP monitoring before surgery, intracranial pressure fluctuations at 1.5 ~ 2.0KPa asked for 4 days, the fourth day due to the occurrence of SVT with decreased blood pressure given adenosine intravenously, a dose of 50μg / kg / times; after every 2 Minutes 50μg, until the total amount of 250μg / kg is still invalid. At the same time, it was found that the mean arterial pressure (MAP) decreased and the ICP increased after each treatment, the dose-related. At a dose of 150 μg / kg, ICP increased from 1.5 to 2.0 kPa in the early stage to 3.0 to 3.5 kPa