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基于少数HIV-1感染者存活10年以上仍保持健康状态而无免疫学缺陷的临床和实验室证据,作者对10例感染HIV-1已12～15年而无临床症状,且CD_4~+细胞计数正常和稳定的血清学阳性病例进行一系列体外实验研究,以期为艾滋病预防和治疗介入的进展提供重要线索。 9例长期存活者血浆培养HIV-1均阴性,但经超敏分支DNA分析,其中4例发现HIV-1 RNA相关颗粒在839～11549个RNA拷贝/ml之间,另5例则低于测定范围(<630个RNA拷贝/ml),这些数字均低
Based on clinical and laboratory evidence that a small number of HIV-1-infected individuals survived for more than 10 years without immunological deficiencies, the authors evaluated 10 HIV-1-infected individuals for 12 to 15 years without any clinical signs of CD8 + cells A series of in vitro experimental studies were performed on normal and stable serologically positive cases in order to provide important clues for the progress of HIV prevention and treatment interventions. Nine of the nine long-term survivors were negative for HIV-1 in culture, but four of the four HIV-1 RNA-associated particles were found to be between 839 and 11549 RNA copies / ml in the four cases, and the other five were lower than the assay Range (<630 RNA copies / ml), all of which are low