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帕金森病 (ＰＤ)作为一种危及人类生存生活质量的老年神经退行性疾病 ,其多种临床表现均与脑区黑质纹状体多巴胺浓度的降低有关 ,故与多巴胺系统代谢相关的基因已成为ＰＤ临床分子遗传学研究的热点。本研究主要探讨多巴胺β羟化酶 (ＤＢＨ)基因内含子 5区Ａ1/Ａ2多态在ＰＤ发病
Parkinson’s disease (PD), as a neurodegenerative neurodegenerative disease that is endangering the quality of life of human beings, has many clinical manifestations related to the decrease of dopamine concentration in the nigrostriatum of the brain. Therefore, the genes related to dopamine metabolism PD clinical molecular genetics become a hot spot. This study focused on the dopamine beta hydroxylase (DBH) gene intron 5 A1 / A2 polymorphism in the pathogenesis of PD