该文探讨了连续数天短时悬尾应激对小鼠十字迷宫空间记忆及其反转学习的作用。81只成年雄性昆明小鼠被分为4大组:绝对空间记忆获得组及巩固组;相对空间记忆获得组及巩固组。每大组又分为悬尾组(每天训练前或训练后立即接受悬尾处理20min)和对照组。结果表明,在空间记忆训练初期,各对照组和悬尾组动物正确反应率无明显差异,均在机遇水平;随着训练天数的增加,对照组成绩显著提高,当其正确反应率达到80%时,悬尾组正确反应率仍处于或略高于机遇水平,两组间差异显著(P<0.01);在反转学习中,悬尾组正确反应率也显著低于对照组(P<0.01)。这些表明,悬尾应激可显著损伤小鼠的空间记忆及其反转学习的获得和巩固,其中相对空间记忆及其反转学习的巩固受损尤为严重。 This article explores the effect of short tail suspension stress on spatial memory and reversal learning in mice for several days. Eighty-one adult male Kunming mice were divided into 4 groups: absolute spatial memory acquisition group and consolidation group; relative spatial memory acquisition group and consolidation group. Each group is divided into suspension group (before training or immediately after training suspension tail 20min) and control group. The results showed that in the early stage of spatial memory training, there was no significant difference in the correct response rate between the control group and the tail-suspended group, all of which were at the opportunity level. With the increase of training days, the scores of the control group significantly increased. When the correct response rate reached 80% , The correct response rate in the tail-suspension group was still at or slightly above the opportunity level, with significant difference between the two groups (P <0.01). In the reverse learning, the correct response rate in the tail-suspension group was also significantly lower than that of the control group (P <0.01) ). These indicate that tail stress can significantly damage the spatial memory of mice and the acquisition and consolidation of their reverse learning, in which the relative spatial memory and its inversion learning are particularly impaired.