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研究了可乐定对梭曼中毒的预防作用 .结果显示试管内可乐定仅在高浓度 ( 1 - 1 0 mmol· L-1)时对 Ch E产生抑制 ,在小鼠体内 1 mg·kg-1,ip时对脑 Ch E也只产生轻微的抑制 .给小鼠先 ip可乐定对梭曼中毒小鼠脑和全血 Ch E活性无明显影响 ,却使中毒小鼠惊厥发生率及死亡率显著下降 .育亨宾可以明显对抗可乐定对梭曼中毒的预防作用 .说明 α2 肾上腺素受体可能介导了可乐定对梭曼中毒的预防作用 .
The preventive effect of clonidine on soman toxicity was studied. The results showed that clonidine inhibited ChE only in high concentration (1 - 10 mmol · L -1), and in vivo, 1 mg · kg -1 , ip when the brain Ch E also produced only a slight inhibition to the mice first ip clonidine mouse Sohuman poisoning and whole blood Ch E activity had no significant effect, but poisoning mice seizures incidence and mortality was significantly Yohimbin can obviously antagonize the preventive effect of clonidine on soman poisoning, indicating that α2 adrenoceptor may mediate the preventive effect of clonidine on soman toxicity.