通常称为亚硝胺的化合物,是一类强烈的化学致癌物质,能诱发许多动物的恶性肿瘤。这类化合物的确切名称是N-亚硝基化合物,其中包括亚硝胺和亚硝酰胺两类。相近似的化合物还有偶氮化合物和三氮烯类化合物。本文暂不涉及这些有关的化合物,只就N-亚硝基化合物,即亚硝胺和亚硝酰胺与恶性肿瘤关系的若干问题的研究进展进行简明的概述。亚硝胺引起人们的注意始于五十年代。1954年,英国某工厂接触以二甲基亚硝胺为溶剂的工种的三名工作人员中,二人患肝硬变,Barnes和Magee研究了这次中毒事件,证明肝硬变确实与接触二甲基亚硝胺有关,随后继续进行了大量的动物实验,证实二甲基亚硝胺能诱发大鼠肝癌。从这以后,亚硝胺作为环境中潜在致癌物的致癌作用引起了各方面研究者的极大的重视。 N-亚硝基化合物在肿瘤病因研究中的重 Compounds commonly known as nitrosamines are a class of intense chemical carcinogens that can elicit many animal malignancies. The exact names of these compounds are N-nitroso compounds, including nitrosamines and nitrosamides. Similar compounds include azo compounds and triazene compounds. This article is not related to these related compounds, only a brief overview of the progress of the N-nitroso compounds, nitrosamines and nitrosamines and cancer research. Nitrosamines attract people’s attention began in the fifties. In 1954, two workers in three factories exposed to dimethylnitrosamine as a solvent in a factory in England were suffering from cirrhosis. Barnes and Magee studied the poisoning incident to prove that cirrhosis did indeed affect contact with two Methyl nitrosamines, followed by a large number of animal experiments continued, confirmed dimethylnitrosamine can induce liver cancer in rats. Since then, the carcinogenicity of nitrosamines as a potential carcinogen in the environment has drawn great attention from researchers in various fields.重. N - nitroso compounds in the etiology of cancer research