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目的研究中保牌健生胶囊的作用。方法采用常压耐缺氧试验、亚硝酸钠中毒存活试验和急性脑缺血性缺氧试验对小鼠进行耐缺氧功能试验。结果经口给予小鼠中保牌健生胶囊0.05、0.50、1.50g/kgBW,连续灌胃30d,高剂量组能延长常压缺氧小鼠缺氧存活时间;中、高剂量能延长亚硝酸钠中毒后存活时间;中剂量组能延长急性脑缺血性缺氧张口喘气时间。结论中保牌健生胶囊在一定剂量范围内具有提高小鼠缺氧耐氧的能力。
Objective To study the role of Zhongbao Health Capsule. Methods The hypoxia tolerance test was carried out in mice with hypoxia tolerance test, sodium nitrite poisoning survival test and acute cerebral ischemia hypoxia test. Results Oral administration of baojian jiansheng capsule at doses of 0.05,0.50,1.50g / kg BW in mice continuously for 30 days, the high dose group can prolong hypoxia survival time in hypobaric hypoxia mice; middle and high doses can prolong sodium nitrite Survival time after poisoning; medium dose group can prolong the acute cerebral ischemic hypoxia mouth gasping time. Conclusion Zhongbao Capsule has the ability to improve hypoxia and oxygen tolerance in mice in a certain dose range.