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目的比较正畸力作用下经釉基质蛋白诱导再生的牙周组织与正常牙周组织中牙齿移动距离的差异,探讨釉基质蛋白治疗牙周疾病后牙齿正畸的可行性。方法选择42只雌性SD大鼠,将上颌两侧第一磨牙分别设为再生牙周组和正常对照组。再生牙周组采用结扎丝结扎法形成大鼠重度牙周炎实验模型,继而采用釉基质蛋白诱导牙周再生进行牙周重建。重建完成后,两组安装正畸加力装置牵引上颌第一磨牙近中移动,牵引4周测量上颌第一磨牙近中移动距离并进行统计学分析。结果两组第一磨牙近中移动距离无统计学差异(P>0.05)。结论经诱导后的重建牙周具有良好的力学反应性,釉基质蛋白可以应用于重度牙周炎正畸牙齿的牙周再生治疗。
OBJECTIVE: To compare the distance of tooth movement between periodontal tissues and periodontal tissues induced by enamel matrix proteins under orthodontic force, and to investigate the feasibility of enamel matrix proteins for orthodontic treatment of periodontal diseases. Methods Forty-two female SD rats were selected, and the first molar on both sides of maxillary was set as regenerative periodontal group and normal control group respectively. Regeneration periodontal group using ligation ligature method to form severe experimental periodontitis rats model, followed by the use of enamel matrix proteins to induce periodontal regeneration for periodontal reconstruction. After the reconstruction was completed, the two groups were mounted orthodontic force device to move the maxillary first molars to near-mid-shift, and the traction was performed for 4 weeks to measure the maxillary first molars near-mid-distance and make statistical analysis. Results There was no significant difference in the distance between the first molars in the two groups (P> 0.05). Conclusion The induced periodontal reconstruction with good mechanical reactivity, enamel matrix protein can be applied to periodontal regeneration of severe periodontitis orthodontic teeth.