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目的探讨18氟-脱氧葡萄糖双探头符合线路单光子计算机断层显像术(18F-FDGSPECT)与增强螺旋CT联合对肺癌淋巴结转移分期的诊断价值。方法163例考虑为肺癌的患者2周内均行18F-FDGDHC-SPECT显像及胸部增强螺旋CT检查,3周内完成外科手术和病理学检查,并将组织病理结果作为参照标准对这两种方法进行比较。结果SPECT真阳性50例,真阴性61例,诊断肺癌淋巴结转移的灵敏度、特异度、阳性预计值、阴性预计值分别为52.6%、89.7%、83.3%、57.7%;CT真阳性44例,真阴性58例,诊断肺癌淋巴结转移的灵敏度、特异度、阳性预计值、阴性预计值分别为46.3%、85.3%、81.5%、53.2%。SPECT对肺癌的N分期与CT相比无显著性差异(P﹥0.05)。结论18F-FDGSPECT和CT作为非创伤性诊断方法在肺癌临床N分期中准确率较低,但这两种检查的联合使用可作为判断肺癌淋巴结有无转移的一种手段。
Objective To investigate the diagnostic value of 18 F-FDG SPECT combined with enhanced spiral CT in the diagnosis of lymph node metastasis of lung cancer by 18 Fluoro-deoxy glucose double probe. Methods Totally 163 patients with lung cancer underwent 18F-FDGDH-SPECT and chest enhanced helical CT within 2 weeks. Surgical and pathological examinations were performed within 3 weeks. Histopathological findings were used as reference standards for both Method to compare. Results The sensitivity, specificity, positive predictive value and negative predictive value of SPECT were 52.6%, 89.7%, 83.3% and 57.7% respectively in 50 cases of true negative and 61 cases of positive lymph node metastasis. CT positive in 44 cases was true The sensitivity, specificity, positive predictive value and negative predictive value of 58 cases were 46.3%, 85.3%, 81.5% and 53.2% respectively, which were negative in diagnosis of lymph node metastasis of lung cancer. There was no significant difference in SP stage between N stage and CT in lung cancer (P> 0.05). Conclusion 18F-FDG SPECT and CT as a non-invasive diagnostic method in the clinical N staging of lung cancer with low accuracy, but the combination of these two tests can be used as a means to determine whether there is lymph node metastasis of lung cancer.