目的探讨大面积脑梗死的危险因素、临床特点、治疗与预后。方法回顾性分析60例大面积脑梗死患者的临床资料。结果 60例大面积脑梗死患者存活46例,死亡14例。结论大面积脑梗死主要危险因素有高血压病、糖尿病、心脏病伴发心律失常、高脂血症,多发生于50岁以上,男性多发,多急性起病,意识障碍多见,以偏瘫、偏身感觉障碍为主要表现,脑疝、肺部感染等是死亡的主要原因,适宜病例早期溶栓,迅速控制脑水肿是治疗的关键。 Objective To explore the risk factors, clinical features, treatment and prognosis of large area cerebral infarction. Methods The clinical data of 60 patients with large area cerebral infarction were retrospectively analyzed. Results Sixty-six patients with large-area cerebral infarction survived and 14 died. Conclusions The main risk factors of large area cerebral infarction are hypertension, diabetes, heart disease with arrhythmia and hyperlipidemia, which occur mostly in patients over 50 years old. Many men have acute onset and acute disturbance of consciousness, with hemiplegia, Skeletal sensory disturbance as the main performance, hernia, lung infection is the main cause of death, suitable for early thrombolysis cases, rapid control of brain edema is the key to treatment.