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目的 分析１２ 例眼眶原发恶性淋巴瘤的放射治疗结果，复习文献，讨论眼眶恶性淋巴瘤的治疗方法。方法 １９５８ 年至１９９７ 年中国医学科学院肿瘤医院收治眼眶原发恶性淋巴瘤１２ 例，Ⅰ期８ 例，Ⅱ期４ 例。１０ 例行单纯放射治疗，２ 例行放射治疗加化疗。放射治疗主要为局部照射，照射剂量 Ｄ Ｔ３０ ～６０ Ｇｙ 。结果 局部控制率１００ ％ ，５ 年生存率８６ ％ 。文献复习显示，眼眶原发恶性淋巴瘤７５ ％ 为低度恶性，单纯放射治疗局部控制率平均９７ ％ ，５ 年生存率６２ ％ ～９３ ％ ，远处复发率为２０ ％ 。结论 局部放射治疗是眼眶原发恶性淋巴瘤有效的治疗方法，低度恶性放射剂量 Ｄ Ｔ ３０ ～３５ Ｇｙ ，中、高度恶性 Ｄ Ｔ ３６ ～４０ Ｇｙ 。
Objective To analyze the radiotherapy results of 12 cases of orbital primary malignant lymphoma, review the literature and discuss the treatment of orbital malignant lymphoma. Methods From 1958 to 1997, 12 cases of orbital primary malignant lymphoma were treated in Cancer Hospital of Chinese Academy of Medical Sciences. There were 8 cases in stage Ⅰ and 4 cases in stage Ⅱ. 10 cases of simple radiotherapy, 2 cases of radiotherapy and chemotherapy. Radiation therapy is mainly for local irradiation, radiation dose D30 ~ 60 Gy. Results Local control rate of 100%, 5-year survival rate of 86%. Literature review showed that 75% of primary orbital malignant lymphoma was low grade malignancy. The average local control rate of radiotherapy alone was 97%, the 5-year survival rate was 62% -93%, and the distant recurrence rate was 20%. Conclusion Local radiotherapy is an effective treatment for primary orbital malignant lymphoma. Low-grade malignant radiation dose is 30-35 Gy for D T and 36- 40 Gy for moderate and high-grade D-T.