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膀胱癌的发生涉及多种遗传因素的改变，如癌基因Ｈ－ｒａｓ，ｍｙｃ，ｅｒｂＢ－１，ｅｒｂＢ－２的激话和抑癌基因Ｒｂ，ｐ５３的失活。随着研究的深入，又有新的遗传改变在膀胱癌中被揭示。膀胱癌的细胞遗传学研究表明，在９ｐ２１－２２存在高频率的缺失。而该位置目前知道
The occurrence of bladder cancer involves a variety of genetic changes, such as the oncogenes H-ras, myc, erbB-1, erbB-2 and the tumor suppressor gene Rb, p53 inactivation. With the deepening of research, there are new genetic changes have been revealed in bladder cancer. Cytogenetic studies of bladder cancer showed a high frequency of deletions at 9p21-22. The location currently knows