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目的分析TIM-3在结肠癌中的表达及其与结肠癌临床特征的关系,探讨TIM-3在结肠癌进展中的作用及其临床意义。方法利用免疫组化检测20组结肠癌癌组织及相对应的正常结肠组织中TIM-3的表达情况,分析TIM-3与患者性别、年龄、肿瘤大小、浸润程度、组织学分级、淋巴结转移、TNM分期等临床病理参数之间的相关性。结果 20例结肠癌组织中TIM-3阳性率70%,正常结肠组织中TIM-3阳性率20%,两者差异有统计学意义(P=0.001);TIM-3与结肠癌的浸润程度、淋巴结转移及TNM分期有关(P<0.05),与性别、年龄、组织学分级、肿瘤大小无关(P>0.05)。TIM-3表达阴性的结肠癌患者5年生存率为66.7%,TIM-3阳性表达的结肠癌患者5年生存率为28.6%,两者差异有统计学意义(P=0.038)。结论结肠癌中TIM-3表达明显增高,TIM-3可能参与结肠癌患者疾病的发生发展进程。因此,TIM-3有望作为结肠癌诊断和预后判断的重要指标。
Objective To analyze the expression of TIM-3 in colon cancer and its relationship with the clinical features of colon cancer, and to explore the role of TIM-3 in the progression of colon cancer and its clinical significance. Methods The expression of TIM-3 in 20 colon cancer tissues and corresponding normal colon tissues was detected by immunohistochemistry. The relationship between TIM-3 and the gender, age, tumor size, infiltration, histological grade, lymph node metastasis, TNM staging and other clinical and pathological parameters of the correlation. Results The TIM-3 positive rate was 70% in 20 cases of colon cancer tissues and 20% in normal colon tissues, the difference was statistically significant (P = 0.001). The infiltration degree of TIM-3 and colon cancer, Lymph node metastasis and TNM stage (P <0.05), but not with gender, age, histological grade and tumor size (P> 0.05). The 5-year survival rate of patients with negative TIM-3 colon cancer was 66.7%, and the 5-year survival rate of patients with TIM-3 positive colon cancer was 28.6%. The difference was statistically significant (P = 0.038). Conclusion The expression of TIM-3 in colon cancer is significantly increased, and TIM-3 may be involved in the pathogenesis of colon cancer. Therefore, TIM-3 is expected as an important indicator of colon cancer diagnosis and prognosis.