Locally advanced colorectal cancer complicated with adjacent organic invasion may remain confined to the local area with minimal metastasis.In the presentpaper,we report on a patient with advanced right colon cancer,including liver,gallbladder,and duodenal invasion behind the scene of liver abscess.En bloc resection was performed on the patient,with right-hemicolectomy,cholecystectomy,partial duodental resection,and hepatectomy.Postoperative management was administered,including nutritional support in the early postoperative period,effective anti-infection treatment,and adjuvant chemotherapy (FOLFOX4).The patient survived for 16 months after the operation.Common clinical manifestations of colorectal cancer were digestive symptoms and changes in defecation.However,the clinical manifestation of locally advanced colon cancer was extremely complicated.Extended or multivisceral resection may offer patients a chance to survive an acute crisis and allow for treatment with adjuvant therapy.