就化学诱导分子水平突变的危险因素、分子机理及DNA损伤检测等方面的研究结果进行了综述。人类的主要致突变危险因素包括膳食、老龄化、慢性炎症、吸烟、环境污染等。DNA损伤的分子机理有DNA加合物形成、碱基取代或构象改变等。新的DNA序列分析技术有可能使损伤检测变得直接、快速、准确 The risk factors, molecular mechanism and DNA damage detection of chemically induced molecular level mutation were reviewed. The main human risk factors for mutation include diet, aging, chronic inflammation, smoking, environmental pollution and so on. The molecular mechanism of DNA damage DNA adduct formation, base substitution or conformational changes. The new DNA sequencing technology makes it possible to make damage detection straightforward, fast and accurate