目的探讨三阴性乳腺癌的临床病理特征及对预后的影响,为临床的防治提供参考。方法回顾性分析中山大学附属五院自2004年7月-2007年7月期间收治的212例乳腺癌患者分为三阴乳腺癌和非三阴性乳腺癌,其中三阴性乳腺癌患者46例,非三阴患者166例,对两组的临床病理特点及预后进行分析。结果三阴组和非三阴组乳腺癌患者临床病理特征进行比较,其中家族史、年龄、绝经状态、临床分期、腋窝淋巴结转移情况、病理类型及组织学分级差异有统计学意义(P<0.05);212例乳腺癌患者进行随访5年,三阴组和非三阴组乳腺癌患者局部复发、远处转移及死亡进行卡方检验,差异有统计学意义(P<0.05);三阴组和非三阴组乳腺癌患者随访3年和5年的无瘤生存率和总生存率进行比较,差异有统计学意义(P<0.05)。结论三阴性乳腺癌具有家族性、发病年龄低、腋窝淋巴结阳性率高、易复发转移、无瘤生存率及总生存率较低等特点,临床预后差。 Objective To investigate the clinicopathological features and prognosis of triple negative breast cancer and provide references for clinical prevention and treatment. Methods A retrospective analysis of Affiliated Hospital of Sun Yat-sen from July 2004 -2007 in July during the treatment of 212 cases of breast cancer were divided into three negative breast cancer and non-triple negative breast cancer, including 46 cases of triple negative breast cancer, non- Three patients with yin and yin 166 cases, the two groups of clinicopathological features and prognosis were analyzed. Results The clinical and pathological characteristics of patients with breast cancer were significantly higher than those with normal controls (P <0.05). The family history, age, menopausal status, clinical stage, axillary lymph node metastasis, pathological type and histological grade were significantly different ). 212 patients with breast cancer were followed up for 5 years. The local recurrence, distant metastasis and death in patients with triple negative and non-triple negative breast cancer were analyzed by chi-square test, the difference was statistically significant (P <0.05) And non-tripeptide breast cancer patients were followed up for 3 years and 5 years, the tumor-free survival rate and overall survival rate were compared, the difference was statistically significant (P <0.05). Conclusions Triple negative breast cancer has familial features, low age of onset, high positive rate of axillary lymph nodes, easy recurrence and metastasis, low tumor-free survival and low overall survival. The clinical prognosis is poor.